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Index > Protein center > LITAF(Gene name) > Human
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  • LITAF (Gene name),
  • Lipopolysaccharide-induced tumor necrosis factor-alpha factor (Protein name ),  LITAF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    LITAF(PIG7;SIMPLE);
    Protein name:
    Lipopolysaccharide-induced tumor necrosis factor-alpha factor(LPS-induced TNF-alpha factor);
    Alternative:
    p53-induced gene 7 protein;Small integral membrane protein of lysosome/late endosome;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with NEDD4 (By similarity). Interacts with WWOX. Isoform 2 may interact with STAT6.
    Function:
    Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.
    Subcellular Location:
    Lysosome membrane Peripheral membrane protein Cytoplasmic side Associated with membranes of lysosomes.
    Protein Attributes:
    Sequence length:
    161
    Sequence:
    50:
    MSVPGPYQAA | TGPSSAPSAP | PSYEETVAVN | SYYPTPPAPM | PGPTTGLVTG | 
    100:
    PDGKGMNPPS | YYTQPAPIPN | NNPITVQTVY | VQHPITFLDR | PIQMCCPSCN | 
    150:
    KMIVSQLSYN | AGALTWLSCG | SLCLLGCIAG | CCFIPFCVDA | LQDVDHYCPN | 
    161:
    CRALLGTYKR | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human LPS-induced TNF-alpha factor
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    E13529c
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    ELISA Kit for Human LPS-induced TNF-alpha factor
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    E13529m
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    ELISA Kit for Human LPS-induced TNF-alpha factor
    Cat.:
    E13529r
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    ELISA Kit for Human LPS-induced TNF-alpha factor
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    E13529h
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    96T
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    CLIA Kit for Human LPS-induced TNF-alpha factor
    Cat.:
    U13529h
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    Packing:
    96T
    CLIA Kit for Human LPS-induced TNF-alpha factor
    Cat.:
    U13529c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human LPS-induced TNF-alpha factor
    Cat.:
    U13529r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LPS-induced TNF-alpha factor
    Cat.:
    U13529m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human LPS-induced TNF-alpha factor
    Cat.:
    P13529Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LPS-induced TNF-alpha factor
    Cat.:
    P13529Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LPS-induced TNF-alpha factor
    Cat.:
    P13529Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LPS-induced TNF-alpha factor
    Monoclonal Antibody for Human LPS-induced TNF-alpha factor
    Monoclonal Antibody for Human LPS-induced TNF-alpha factor
    Monoclonal Antibody for Human LPS-induced TNF-alpha factor
    Monoclonal Antibody for Human LPS-induced TNF-alpha factor
    Protein for Human LPS-induced TNF-alpha factor
    Protein for Human LPS-induced TNF-alpha factor
    Protein for Human LPS-induced TNF-alpha factor
    Protein for Human LPS-induced TNF-alpha factor

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION BY TP53
      tissue: Colon cancer.
    2. 2.
      "A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment."
      Myokai F. , Takashiba S. , Lebo R. , Amar S.
      Proc. Natl. Acad. Sci. U.S.A.96:4518-4523(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INDUCTION;TISSUE SPECIFICITY
      tissue: Monocyte.
    3. 3.
      "Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1."
      Moriwaki Y. , Begum N.A. , Kobayashi M. , Matsumoto M. , Toyoshima K. , Seya T.
      J. Biol. Chem.276:23065-23076(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INDUCTION;SUBCELLULAR LOCATION
      tissue: Monocyte.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Hair follicle dermal papilla.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Esophageal carcinoma.
    6. 6.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
      tissue: Pancreas.
      tissue: PNS.
      tissue: Skin.
    9. 9.
      "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins."
      Ludes-Meyers J.H. , Kil H. , Bednarek A.K. , Drake J. , Bedford M.T. , Aldaz C.M.
      Oncogene23:5049-5055(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWOX;DOMAIN;MUTAGENESIS OF TYR-23 AND TYR-61
    10. 10.
      "LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines."
      Tang X. , Marciano D.L. , Leeman S.E. , Amar S.
      Proc. Natl. Acad. Sci. U.S.A.102:5132-5137(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT6
    11. 11.
      "Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C."
      Street V.A. , Bennett C.L. , Goldy J.D. , Shirk A.J. , Kleopa K.A. , Tempel B.L. , Lipe H.P. , Scherer S.S. , Bird T.D. , Chance P.F.
      Neurology60:22-26(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMT1C SER-112; ASN-115 AND GLY-116
    12. 12.
      "PIG7/LITAF gene mutation and overexpression of its gene product in extramammary Paget's disease."
      Matsumura Y. , Matsumura Y. , Nishigori C. , Horio T. , Miyachi Y.
      Int. J. Cancer111:218-223(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EMPD HIS-23
    13. 13.
      "Early onset neuropathy in a compound form of Charcot-Marie-Tooth disease."
      Meggouh F. , de Visser M. , Arts W.F.M. , De Coo R.I.F.M. , van Schaik I.N. , Baas F.
      Ann. Neurol.57:589-591(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMT1C SER-112;VARIANT VAL-92
    14. 14.
      "SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation."
      Saifi G.M. , Szigeti K. , Wiszniewski W. , Shy M.E. , Krajewski K. , Hausmanowa-Petrusewicz I. , Kochanski A. , Reeser S. , Mancias P. , Butler I. , Lupski J.R.
      Hum. Mutat.25:372-383(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMT1C MET-49; SER-112 AND VAL-122;VARIANT VAL-92
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